5 Simple Techniques For https://www.ceesdekker.net
5 Simple Techniques For https://www.ceesdekker.net
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Rotary motion of DNA rotors on nanopores. Top row: raw video with the Cy5 channel of each rotor. Center row: corresponding single-particle localization results of both equally ends of your DNA rotors. The placement of the present frame is marked as orange and blue dots, as well as trajectory of the 10 frames before The present body is proven as good traces.
Our group scientific studies bacterial cell division and is aiming to represent a ‘bottom up biology’ in synthetic cells that can autonomously divide. Our most important fascination lies in cell division, chromatin structure, and spatial Command.
Multicolor imaging of the bacterial nucleoid and mobile division proteins with blue, orange, and around-infrared fluorescent proteins
Considering that 2000, Dekker has shifted the main target of his do the job in the direction of biophysics the place he experiments the properties of solitary biomolecules and cells utilizing the instruments of nanotechnology. This change of area was pushed by his fascination for that remarkable functioning of biological molecular constructions, and by the extended-expression point of view that numerous interesting discoveries may be anticipated In this particular subject.[five] Present-day strains of research in his biophysics team are in the areas of:[6]
2015, discovery that condensin can be a hugely flexible protein composition; and initially detection of DNA knots making use of nanopores
SMC complexes can move Bodily roadblocks bigger than their ring size, indicating a nontopological system for DNA loop extrusion
Size control of individual carbon nanotubes by nanostructuring with the scanning tunneling microscope
He also found time to put in writing several textbooks, mail Virtually forty thousand tweets and guide An effective investigate group at Delft College of Technology. ‘It doesn’t come to feel like work’, he states. ‘I’m just terribly curious.’
In 1993, as being a younger and keen affiliate professor at Delft University of Technological innovation, I'd initially targeted the exploration efforts of my group on measuring the electrical conductance of an individual conducting-polymer molecule. Within just two many years, we had designed a tool by which an individual wire of the phthalocyaninepolysiloxane polymer was related amongst two intently spaced metal nanoelectrodes.
Resolving the move sizing in condensin-pushed DNA loop extrusion identifies ATP binding given that the action-generating process
FtsZ treadmilling is essential for Z-ring condensation and septal constriction initiation in bacterial cell division
Afterwards we spoke once more briefly due to the fact Dekker felt that our dialogue of his religion quickly became purely philosophical, While What's more, it concretely allows him in his function.
Visualization of unstained DNA nanostructures with State-of-the-art in-aim transmission electron microscopy methods
2013, controlled shaping of live bacterial cells into arbitrary designs; and discovery of ceesdekker spontaneous fluctuations within the handedness of histone tetrasomes